I've read a number of Wendig's books on writing so this is a rehash of old material for me, or so I find. Nonetheless it also contained many helpful tidbits that I as a writer really needed to hear at this stage in the game. I think that the book best serves writers, in fact, because Wendig doesn't give nuts and bolts examples of how to accomplish a particular thing (like how to make characters interesting, for example. he just says you ought to strive towards making your characters interesting). Instead, it's a good reminder for authors about what and what not to do. It's also easily absorbed thanks to the twenty five things format.
Annoyances: Sometimes the shtick wears a little thin. Wendig is known for his over the top style and crazy analogies. A lot of times this is fun. Sometimes though it felt like he was trying too hard. Also started to get irritated by the constant references to "hobos" as if hobos aren't real people.